Structural effects of linkage disequilibrium on the transcriptome
نویسندگان
چکیده
منابع مشابه
Structural effects of linkage disequilibrium on the transcriptome.
A majority of SNPs (single nucleotide polymorphisms) map to noncoding and intergenic regions of the genome. Noncoding SNPs are often identified in genome-wide association studies (GWAS) as strongly associated with human disease. Two such disease-associated SNPs in the 5' UTR of the human FTL (Ferritin Light Chain) gene are predicted to alter the ensemble of structures adopted by the mRNA. High-...
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ژورنال
عنوان ژورنال: RNA
سال: 2011
ISSN: 1355-8382
DOI: 10.1261/rna.029900.111